Carbamazepine solution
Carbamazepine-d10
CAS: 298-46-4
Molecular Formula: C15H12N2O
Carbamazepine solution - Names and Identifiers
| Name | Carbamazepine-d10 |
| Synonyms | CARBAMAZEPIN carbamazepine CARBAMAZEPINE Carbamazepine-d10 CarbaMazepine-13C6 Carbamazepine solution Oxcarbazepine IMpurity A 5-carbamoyl-5h-dibenz[b,f]azepine 5h-dibenz[b,f]azepine-5-carboxamide 5H-dibenzo[b,f]azepine-5-carboxamide |
| CAS | 298-46-4 |
| EINECS | 206-062-7 |
| InChI | InChI=1/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18) |
Carbamazepine solution - Physico-chemical Properties
| Molecular Formula | C15H12N2O |
| Molar Mass | 236.27 |
| Density | 1.1099 (rough estimate) |
| Melting Point | 191-192 °C (lit.) |
| Boling Point | 378.73°C (rough estimate) |
| Flash Point | 9℃ |
| Water Solubility | pract. insoluble |
| Solubility | Soluble in ethanol, acetone, propylene glycol, insoluble in water. |
| Vapor Presure | 5.78E-07mmHg at 25°C |
| Appearance | White or white-like crystalline powder. |
| Color | Almost white |
| Merck | 14,1781 |
| pKa | 13.94±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5906 (estimate) |
| MDL | MFCD00005073 |
| Physical and Chemical Properties | Melting point 189-192°C water-soluble pract. insoluble |
| Use | Anticonvulsants for grand mal epilepsy and psychomotor epilepsy, also for trigeminal neuralgia |
Carbamazepine solution - Risk and Safety
| Risk Codes | R42/43 - May cause sensitization by inhalation and skin contact. R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S37 - Wear suitable gloves. S24 - Avoid contact with skin. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | HN8225000 |
| HS Code | 29339900 |
| Toxicity | LD50 orally in mice, rats: 3750, 4025 mg/kg (Stenger, Roulet) |
Carbamazepine solution - Reference
| Reference Show more | 1. Li Rongrong, Zhao Di, Li monmeng, Shu Shengnan, Wang peyang, Li Huanru, Feng Suxiang. Metabolites of main components in Fritillaria Thunbergii and pericarpium citri reticulatae in rats based on UHPLC-Q Exactive-Orbitrap high resolution mass spectrometry [J]. Journal of Pharmaceutical Analysis, 2020, v.40(08):86-97. 2. Sun Jiangyan, Liu Chongchong, Yuan Siyuan, Wang Xiaohui, Liu Jinmin. Effects of chaibei Zhixian decoction and its main blood component saikosaponin a on the brain distribution of carbamazepine in epilepsy model rats [J]. Journal of Traditional Chinese Medicine, 2019,60(08):689-695. 3. Liu Chongchong, Sun Jiangyan, Dong Xiaoke, Wang Kaiyue, Li Zhonghao, Wu Min, Li Lili, Liu Jinmin. Effect and mechanism of chaibei Zhixian decoction and its absorption component beimine A on carbamazepine content in rat brain [J]. Chinese Journal of Experimental prescriptions, 2019,25(19):32-38. 4. Li Rongrong, Zhao Di, Li monmeng, Shu Shengnan, Wang peyang, Li Huanru, Feng Suxiang. Metabolites of main components in Fritillaria Thunbergii and pericarpium citri reticulatae in rats based on UHPLC-Q Exactive-Orbitrap high resolution mass spectrometry [J]. Journal of Pharmaceutical Analysis, 2020,40(08):1413-1424. 5. [IF = 1.902] Yining Zhao et al."Simultaneous quantification of 23 bioactive compounds in Tanreqing capsule by high-performance liquid chromatography." Biomed Chromatogr. 2019 Jul;33(7):e4531 6. [IF = 6.639] Fanchao Meng et al.. "Cancers. Oct 2019; 11(10):1571 7. [IF=6.4] Jing Zhao et al."Natural Nano-Drug Delivery System in Coptidis Rhizoma Extract with Modified Berberine Hydrochloride Pharmacokinetics."Int J Nanomed. 2021; 16: 6297-6311 8. [IF=5.81] Zhao Jing et al."Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice."Front Pharmacol. 2021 Jun;0:1426 9. [IF=1.902] Tingting Liu et al."Pharmacokinetic-pharmacodynamic modeling analysis and anti-inflammatory effect of Wangbi capsule in the treatment of adjuvant-induced arthritis."Biomed Chromatogr. 2021 Jul;35(7):e5101 10. [IF=0.837] Shi Xiangjun et al."Preparation and In Vitro/Vivo Evaluation of New Celecoxib Solid Dispersions with Co-Carrier Containing Aerosil and Poloxamer 188."Pharm Chem J . 2021 Jan;54(10):1033-1039 11. [IF=7.312] Yunyun Li et al."Mass transfer enhancement for rapid, selective extraction of pharmaceuticals by enlarging the microporous on isostructural zeolitic imidazolate Framework-8."SEPARATION AND PURIFICATION TECHNOLOGY. 2022 Jul;293:121102 |
Carbamazepine solution - Standard
Authoritative Data Verified Data
This product is 5h-dibenzo [6,f] Nitrogen weed-5-carboxamide. The content of C15H12N20 shall be 98.0% ~ 102.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
Carbamazepine solution - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Almost odorless.
- This product is soluble in chloroform, slightly soluble in ethanol, almost insoluble in water or ether.
melting point
The melting point of this product (General 0612) is 189~193°C.
Last Update：2022-01-01 11:36:51
Carbamazepine solution - Differential diagnosis
Authoritative Data Verified Data
- take about 0.1g of this product, add 2ml of nitric acid, put it on a water bath and heat it, then it will appear orange-red.
- take this product, dissolve and dilute with ethanol to make a solution containing 10ug per lml, and measure by UV-Vis spectrophotometry (General 0401), there is a maximum absorption at a wavelength of 238mn and 285nm, and an absorbance at a wavelength of 285mn is 0.47 to 0.51.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 94).
Last Update：2022-01-01 11:36:51
Carbamazepine solution - Exam
Authoritative Data Verified Data
pH
take L. 0g of this product, add water 20ml, stir for 15 minutes, filter, take the filtrate 10ml, add phenolphthalein indicator solution 1 drop, with sodium hydroxide titration solution (0.Olmol/L) titration, consumption of sodium hydroxide titration solution (0.Olmol/L) should not pass 0.50; Add 3 drops of Methyl red indicator solution, and use hydrochloric acid titration solution (0.Olmol/L) titration, consumption of hydrochloric acid titration solution (0.Olmol/L) should not exceed 1.0 mL.
chloride
take this product l. Add 100ml of water, boil, cool, filter, take 50ml of filtrate, check according to law (General rule 0801), and standard sodium nitride solution 7.0ml of the control solution should not be more concentrated (0.014%).
Related substances
take about 50mg of this product, put it in a 50ml measuring flask, add 25ml of methanol to dissolve it, dilute it with water to scale, shake it well, and use it as a test solution, place in 50rnl measuring flask, dilute to scale with methanol-water (1:1), shake well, take 5ml accurately, put in 50ml measuring flask, use methanol-water (1:1) dilute to the scale, shake, as a control solution. According to the chromatographic condition test under the content determination item, take the control solution and the test solution with 20 u1 respectively, and inject the human liquid chromatograph respectively, the chromatogram was recorded to 6 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.2% ) , and the sum of each impurity peak area shall not be greater than 2.5 times (0.5%) of the area of the main peak of the control solution..
loss on drying
take this product, dry at 105°C for 2 hours, loss of weight shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
precious metals
The residue left under the item of burning and flooding shall be inspected according to law (general law 0821, Law II) and shall not contain more than 10 parts per million of heavy metals.
Last Update：2022-01-01 11:36:52
Carbamazepine solution - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with cyanopropylsilane as filler; Methanol-tetrahydrofuran-water (120:30:850) as the mobile phase (1000ml containing 0.2ml formic acid and 0.5ml triethylamine detection wavelength of 230nm carbamazepine control sample about 25mg, 100ml flask, plus methylol-water (1:1)) dissolve the solution and dilute to the scale, shake well, take 20ul injection liquid chromatograph, and calculate the number of theoretical plates according to carbamazepine peak to be not less than 5000. The separation degree of carbamazepine peak and adjacent impurity peaks should meet the requirements.
assay
take about 50mg of this product, weigh it accurately, put it in a 50ml measuring flask, add methylated 25ml, shake to dissolve, dilute it with water to the scale, shake it well, take 5ml with precision, dilute the flask with methanol-water (1:1) solution to scale, shake well, inject 20ul into human liquid chromatograph with precision, record the chromatogram, and take the reference substance of carbamazepine, same method determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:36:53
Carbamazepine solution - Category
Authoritative Data Verified Data
antiepileptic drugs.
Last Update：2022-01-01 11:36:53
Carbamazepine solution - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:36:53
Carbamazepine solution - Carbamazepine tablets
Authoritative Data Verified Data
This product contains carbamazepine (C15H12N20) should be 95.0% to 105.0% of the label.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product and show the same results according to the identification tests (1) and (2) under the item of carbamazepine.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- for related substances, take an appropriate amount of fine powder (about 50mg equivalent to carbamazepine) under the content determination item, put it in a 50ml measuring flask, add about 25ml of methanol, shake to dissolve carbamazepine, dilute with water to the scale, shake, filter, and take the filtrate as the test solution; Take 1ml, put it in a 50ml measuring flask, use methanol-water (1:1) dilute to the scale, shake, accurately take 5ml, put in 50ml measuring flask, dilute to the scale with methanol-water (1:1), shake, as a control solution. Determination according to the method under carbamazepine related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.2% ) , and the sum of each impurity peak area shall not be greater than 2.5 times (0.5%) of the area of the main peak of the control solution..
- dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), with dilute hydrochloric acid 24ml and water to 1000ml as the dissolution medium, the speed of 75 revolutions per minute (0.lg specifications) or speed of 150 revolutions per minute (0.2g specifications), according to the operation, after 60 minutes, take the solution 10ml, filtration, precision take the appropriate amount of filtrate, dilute the solution with dissolution medium to 6 ~ 15ug per 1 ml, and measure the absorbance at the wavelength of 285nm by UV-Vis spectrophotometry (General rule 0401), the elution amount of each tablet was calculated as an absorption coefficient of C15H12N20 of 518. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about equivalent to 50mg of carbamazepine), put it in a 50ml measuring flask, add about 25ml of methanol, shake to dissolve carbamazepine, dilute to the scale with water, shake well, filter, Take 5ml of continuous filtrate precisely, put it in 25ml measuring flask, use methanol-water (1:1) dilute to the scale, shake, as a test solution. According to the determination of carbamazepine content under the item of the method of determination, that is obtained.
category, storage
Same as carbamazepine.
specification
(1)0.lg (2)0.2g
Last Update：2022-01-01 11:36:54
Carbamazepine solution - Carbamazepine Capsules
Authoritative Data Verified Data
This product contains carbamazepine (C15H12N20) should be 95.0% to 105.0% of the label.
trait
The content of this product is white or white powder.
identification
- (1) taking an appropriate amount of the contents of this product, the same results were obtained according to the identification tests (1) and (2) under the item of carbamazepine.
- (2) in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- for related substances, take an appropriate amount of fine powder (about 50mg equivalent to carbamazepine) under the content determination item, put it in a 50ml measuring flask, add about 25ml of methanol, shake to dissolve carbamazepine, dilute with water to the scale, shake, filter, and take the filtrate as the test solution; Take 1ml, put it in a 50ml measuring flask, use methanol-water (1:1) dilute to the scale, shake, accurately take 5ml, put in 50ml measuring flask, dilute to the scale with methanol-water (1:1), shake, as a control solution. Determination according to the method under carbamazepine related substances. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.2%), and the sum of each impurity peak area shall not be greater than 2.5 times (0.5%) of the area of the main peak of the control solution..
- dissolution: according to the dissolution and release determination method (General rule 0931 second method), dilute hydrochloric acid (24ml) was added with water (ML) as the dissolution medium, and the rotation speed was 75 rpm, operate in accordance with the law, after 60 minutes, take 10ml of solution, filter, take the appropriate amount of filtrate, dilute with dissolution medium to prepare 6 ~ 15ug solution per lml, the absorbance was measured at a wavelength of 0401 NM according to UV-Vis spectrophotometry (General Rule 518), and the dissolution rate of each particle was calculated as the absorption coefficient of C15H12N20 was. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
take the contents under the difference of loading amount, mix evenly, weigh an appropriate amount (about 50mg equivalent to carbamazepine) accurately, put it in a 50ml measuring flask, and add about 25ml of methanol, shake to dissolve carbamazepine, dilute to the scale with water, shake well, filter, Take 5ml of continuous filtrate precisely, put it in 25ml measuring flask, use fermentation-water (1:1) the solution was diluted to the scale and shaken to a test solution. According to the determination of carbamazepine content under the item of the method of determination, that is obtained.
category
Same as carbamazepine.
specification
0.2g
storability
light shielding, sealed storage.
Last Update：2022-01-01 11:36:54
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Multiple SpecificationsSpot supply
Product Name: Oxcarbazepine Impurity 1（Oxcarbazepine EP Impurity A） Visit Supplier Webpage Request for quotationCAS: 298-46-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Carbamazepine-d10 Request for quotation
CAS: 298-46-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 298-46-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Carbamazepine Visit Supplier Webpage Request for quotationCAS: 298-46-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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